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Dogancan Ozturan
Dogancan Ozturan

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Transcription factors perform a 2-step search of the nucleus

https://academic.oup.com/genetics/article-lookup/doi/10.1093/genetics/iyac111

I found this article fascinating. The idea of IDRs reducing the search space for DNA binding domains for their action also aligns with the idea that maybe those “protein clouds” or “transcription regulatory complexes” are always kinetic and constantly changing its constituents. Since they help each other to find these “clouds”, they also work as guides for each other. This also opens up the question of how initial TF or TFs could recognize the binding site. I guess it relies on the stochastic process and once the correct TF finds itself bound to one of the correct regions, then whole machinery starts to form and IDRs begin to help other TFs to find their position along the DNA. Great stuff.

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