https://www.biorxiv.org/content/10.1101/2023.02.25.530020v2
The paper presents a comprehensive analysis of the 3D genome architecture of cerebellar granule cells (GCs) over the lifespan, providing new insights into the regulation of gene expression in these cells. They use cutting-edge techniques such as Hi-C, ChIP-seq, and RNA-seq.
It sheds light on the dynamic nature of chromatin organization in GCs and its role in cell differentiation and maturation.
However, the study focuses exclusively on cerebellar GCs, and therefore the generalizability of the results to other cell types or brain regions is unclear.
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